Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains

Clin Infect Dis. 2007 Sep 1;45(5):594-8. doi: 10.1086/520658. Epub 2007 Jul 17.


Multidrug-resistant Acinetobacter baumannii infection has presented a global medical challenge. The antibiograms of paired colistin-susceptible and -resistant strains revealed increased susceptibility of colistin-resistant strains to most tested antibiotics, including those that are active against only gram-positive bacteria. Synergy between colistin and rifampicin was observed in the colistin-susceptible strains. The ability to form biofilm in the colistin-resistant strains was significantly lower (P<.001) than in the parent strains. Our study provides valuable information for potential expansion of our current therapeutic options against colistin-resistant A. baumannii infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / drug therapy*
  • Acinetobacter baumannii / drug effects*
  • Anti-Bacterial Agents / pharmacology
  • Biofilms / drug effects
  • Colistin / analogs & derivatives
  • Colistin / pharmacokinetics
  • Colistin / pharmacology
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Rifampin / pharmacology


  • Anti-Bacterial Agents
  • colistinmethanesulfonic acid
  • Rifampin
  • Colistin