Hyperglycemia and hypertriglyceridemia may associate with the adenoma-carcinoma transition in colorectal epithelial cells

J Gastroenterol Hepatol. 2008 Jun;23(6):985-7. doi: 10.1111/j.1440-1746.2007.05072.x. Epub 2007 Aug 6.


Background and aim: Epidemiological studies have suggested the positive correlation between hyperlipidemia and/or hyperglycemia and colorectal cancer risk.

Methods: We retrospectively examined the association between fasting blood sugar (BS) or triglycerides (TG) and the presence of colorectal adenoma, carcinoma in situ and invasive cancer in 867 patients who received total colonoscopy by medical health check.

Results: An increased TG level, but not a BS level, was significantly associated with the increased risk of adenoma, although with non-independent multivariate analysis. In contrast, an elevated BS level was identified as an independent risk factor for invasive cancer in 93 patients with carcinoma lesions with an odds ratio of 1.74 (P < 0.05).

Conclusion: Our data suggest that hypertriglyceridemia and hyperglycemia may correlate with the development of adenoma and invasive cancer, respectively. The effectiveness of strict BS control in patients with hypertriglyceridemia for the prevention of the invasive colorectal carcinoma deserves further studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / metabolism
  • Adenoma / pathology*
  • Carcinoma / metabolism
  • Carcinoma / pathology*
  • Carcinoma in Situ / metabolism
  • Cell Transformation, Neoplastic / metabolism*
  • Colonoscopy
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Female
  • Humans
  • Hyperglycemia / complications*
  • Hypertriglyceridemia / complications*
  • Japan / epidemiology
  • Male
  • Mass Screening
  • Multivariate Analysis
  • Odds Ratio
  • Retrospective Studies
  • Risk Factors