The TCF7L2 locus and type 1 diabetes

BMC Med Genet. 2007 Aug 3;8:51. doi: 10.1186/1471-2350-8-51.

Abstract

Background: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D).

Methods: The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent.

Results: This study found no T1D association with, and no age-of-onset effect from rs7903146.

Conclusion: This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Diabetes Mellitus, Type 1 / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Polymorphism, Single Nucleotide
  • TCF Transcription Factors / genetics*
  • Transcription Factor 7-Like 2 Protein

Substances

  • TCF Transcription Factors
  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein