Endocrine regulation of ageing

Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91. doi: 10.1038/nrm2234.


Over the past 15 years it has become clear that mutations in genes that regulate endocrine signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine signalling in a group of cells or a single tissue, which indicates that crosstalk between tissues functions to coordinate ageing of the organism. These endocrine pathways might serve as targets for the manipulation of the ageing process and prevention of age-related diseases.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Endocrine System / physiology*
  • Glucuronidase / genetics
  • Glucuronidase / pharmacology
  • Humans
  • Insulin / physiology
  • Longevity / physiology
  • Signal Transduction*


  • Insulin
  • Glucuronidase
  • klotho protein