[Effect of L-arginine supplementation on secretion of human growth hormone and insulin-like growth factor in adults]

Arq Bras Endocrinol Metabol. 2007 Jun;51(4):587-92. doi: 10.1590/s0004-27302007000400013.
[Article in Portuguese]


Based on presumptions that the infusion of amino acids can augment the release of human growth hormone (hGH) and that this metabolism is related with secretion of insulin-like growth factor I (IGF-I), the purpose of this study was to verify the effect of L-arginine supplementation on GH and IGF-I in adults. Seventeen male individuals participated on the study and were randomized to receive L-arginine (n= 10) or placebo (n= 7), seven grams per day for seven days. Before and after the supplementation period, the volunteers realized blood collection in fasting to verify both GH and IGF-I levels, as well as urine collection to verify urea excretion. At the end of the experimental period, it was verified that the group that received L-arginine augmented the urea in urine excretion (to 2684.1 +/- 475.2 mg/dl from 2967.2 +/- 409.7 mg/dl, p= 0.002), therefore it did not alter significantly the release of hormones evaluated. The group which received placebo did not alter significantly any evaluated parameters. The L-arginine supplementation during seven days was ineffective to augment both GH and IGF-I release in individual male adults.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine / administration & dosage*
  • Dietary Supplements*
  • Human Growth Hormone / blood
  • Human Growth Hormone / drug effects
  • Human Growth Hormone / metabolism*
  • Humans
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor I / metabolism*
  • Male
  • Placebos
  • Urea / urine


  • Placebos
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Urea
  • Arginine