A comparative study between ketorolac and ketoprofen in postoperative pain after uvulopalatopharyngoplasty

Braz J Otorhinolaryngol. 2007 May-Jun;73(3):339-42. doi: 10.1016/s1808-8694(15)30077-x.

Abstract

Postoperative pain is a serious problem, requiring an appropriate response from the medical doctor. In otolaryngology special attention is needed after uvulopalatopharyngoplasty (UP3).

Aim: To compare the efficacy of postoperative analgesia using ketorolac and ketoprofen after UP3.

Patients and methods: A prospective, randomized, double-blind study was made of 24 patients that were divided into 2 groups (14 received ketorolac and 10 received ketoprofen). Pain intensity was based on an analog visual scale and the need for opioids (tramadol).

Results: Of the 13 patients that received ketorolac, 3 (21%) required opioids; 7 of 10 (70%) patients in ketoprofen group used opioids. 12 hours after surgery, 71% of the patients that received ketorolac had mild or absence of pain. 70% of the ketoprofen users reported moderate to significant pain. 24 hours after surgery, 60% of the patients using ketoprofen reported moderate to significant pain, while 86% of the ketorolac users reported mild or absence of pain.

Conclusion: We concluded that ketorolac is more effective compared to ketoprofen in the treatment of immediate postoperative pain after UP3, as patients using ketorolac had less pain and used opioids to a lesser degree.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Analgesics, Opioid / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Ketoprofen / therapeutic use*
  • Ketorolac / therapeutic use*
  • Male
  • Pain Measurement
  • Pain, Postoperative / drug therapy*
  • Palate, Soft / surgery*
  • Pharynx / surgery*
  • Prospective Studies
  • Tramadol / therapeutic use
  • Uvula / surgery

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Tramadol
  • Ketoprofen
  • Ketorolac