[Calcium and Blood Pressure]

Ther Umsch. 2007 May;64(5):249-52. doi: 10.1024/0040-5930.64.5.249.
[Article in German]

Abstract

The regulation of blood pressure is complex with several organs being involved. Intracellular calcium plays a crucial role in the regulation of cardiovascular functions: An increased influx of calcium into the vascular smooth muscle cells leads to an augmental muscular tone and therefore to an increased vascular resistance and rise in blood pressure. Parathormone plays a permissive role since it regulates the calcium-influx into the cells and thus increases the vasoconstrictive effect. There is a positive correlation between parathormone and blood pressure, present in primary as well as secondary hyperparathyroidism. Moreover, patients with essential hypertension have high parathormone levels already before hypertension is diagnosed. A calcium-rich diet (> 1000 mg calcium daily) slightly decreases blood pressure. This positive effect is due to parathormone suppression with a subsequently decreased calcium content in the vascular smooth muscle cells. A calcium-rich diet inhibits lipogenesis in the fat tissue; thus additionally improving the cardiovascular risk profile.

Publication types

  • English Abstract

MeSH terms

  • Blood Pressure / physiology*
  • Calcium / administration & dosage
  • Calcium / blood*
  • Calcium, Dietary / administration & dosage
  • Humans
  • Hypertension / drug therapy
  • Hypertension / physiopathology*
  • Lipogenesis / physiology
  • Lipolysis / physiology
  • Muscle, Smooth, Vascular / physiopathology
  • Obesity / physiopathology
  • Parathyroid Hormone / blood
  • Vascular Resistance / physiology

Substances

  • Calcium, Dietary
  • Parathyroid Hormone
  • Calcium