Vitamin D Serum Levels and Allergic Rhinitis

Allergy. 2007 Sep;62(9):1085-6. doi: 10.1111/j.1398-9995.2007.01437.x.


In addition to its role in the regulation of calcium metabolism, vitamin D has a number of immunological effects. Several studies in children found an effect of oral supplementation on allergic sensitization but so far there are no population-based studies of vitamin D serum levels. We therefore examined 25(OH)-D(3) status in 18,224 adults of the Third National Health and Nutrition Examination Survey. There was no effect on sensitization to a single allergen while the prevalence of allergic rhinitis increased across quartile groups of current vitamin D serum levels. The association could be due to unrecognized confounding, however, could also point towards an altered metabolism or an increased sensitivity to vitamin D in allergic patients.

MeSH terms

  • Adult
  • Allergens / adverse effects
  • Allergens / immunology
  • Calcifediol / blood*
  • Humans
  • Rhinitis, Allergic, Seasonal / blood*
  • Rhinitis, Allergic, Seasonal / epidemiology
  • Rhinitis, Allergic, Seasonal / immunology
  • Skin Tests
  • United States / epidemiology


  • Allergens
  • Calcifediol