Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Breast Cancer Res Treat. 2008 Jul;110(2):223-6. doi: 10.1007/s10549-007-9713-6. Epub 2007 Aug 9.

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / therapy*
  • Cytokines / metabolism
  • DNA / metabolism
  • Female
  • Genetic Therapy / methods*
  • Humans
  • Interleukin-12 / genetics*
  • Mammary Neoplasms, Animal / genetics*
  • Mammary Neoplasms, Animal / therapy*
  • Mammary Tumor Virus, Mouse / metabolism
  • Mice
  • Mice, Nude
  • Mice, Transgenic
  • Neoplasm Metastasis
  • Neoplasm Transplantation

Substances

  • Cytokines
  • Interleukin-12
  • DNA