Anterior thalamic nucleus stimulation for epilepsy

Acta Neurochir Suppl. 2007;97(Pt 2):343-6. doi: 10.1007/978-3-211-33081-4_39.


One option for treatment of medically refractory debilitating epilepsy is stimulation of the anterior thalamic nucleus, which projects via the cingulate gyrus to limbic structures and neocortex. In this chapter we describe the technique for anterior thalamic deep brain stimulation and report outcomes of early series of patients. The prospective double-blind randomized Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) trial will evaluate the efficacy of this technique for epilepsy treatment.

Publication types

  • Review

MeSH terms

  • Anterior Thalamic Nuclei / physiopathology*
  • Deep Brain Stimulation / methods*
  • Epilepsy / pathology*
  • Epilepsy / therapy*
  • Humans
  • Magnetic Resonance Imaging / methods