The nuclear pore complex: oily spaghetti or gummy bear?

Cell. 2007 Aug 10;130(3):405-7. doi: 10.1016/j.cell.2007.07.029.

Abstract

In this issue, Frey and Görlich (2007) provide new insight into the selective barrier that controls protein traffic through the nuclear pore complex. They show that a single protein domain of the nuclear pore protein Nsp1 can form a hydrogel that allows highly selective access of nuclear transport receptors and their cargos, but rejects other proteins of similar size.

Publication types

  • Comment
  • Review

MeSH terms

  • Calcium-Binding Proteins / chemistry
  • Calcium-Binding Proteins / metabolism
  • Humans
  • Nuclear Pore / chemistry*
  • Nuclear Pore / metabolism
  • Nuclear Pore / physiology*
  • Nuclear Pore Complex Proteins
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism
  • Protein Transport / physiology
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Calcium-Binding Proteins
  • NSP1 protein, S cerevisiae
  • Nuclear Pore Complex Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins