Intraventricular hemorrhage from ruptured aneurysm: clinical characteristics, complications, and outcomes in a large, prospective, multicenter study population

J Neurosurg. 2007 Aug;107(2):261-5. doi: 10.3171/JNS-07/08/0261.


Object: In this study the authors analyzed the relationship of intraventricular hemorrhage (IVH) to in-hospital complications and clinical outcome in a large population of patients with aneurysmal subarachnoid hemorrhage (SAH).

Methods: Data from 3539 patients with aneurysmal SAH were evaluated, and these data were obtained from four prospective, randomized, double-blind, placebo-controlled trials of tirilazad that had been conducted between 1991 and 1997. Clinical characteristics, in-hospital complications, and outcome at 3 months post-SAH (Glasgow Outcome Scale score) were analyzed with regard to the presence or absence of IVH.

Results: Patients with SAH and IVH differ in demographic and admission characteristics from those with SAH but without IVH and are more likely to suffer in-hospital complications and a worse outcome at 3 months post-SAH.

Conclusions: The presence of IVH in patients with SAH has an important predictive value with regard to these aspects.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aneurysm, Ruptured / complications*
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / drug therapy
  • Cerebral Hemorrhage / etiology*
  • Cohort Studies
  • Double-Blind Method
  • Female
  • Glasgow Outcome Scale
  • Humans
  • Intracranial Aneurysm / complications*
  • Male
  • Middle Aged
  • Neuroprotective Agents / therapeutic use
  • Pregnatrienes / therapeutic use
  • Prognosis
  • Subarachnoid Hemorrhage / complications*
  • Subarachnoid Hemorrhage / diagnosis*
  • Subarachnoid Hemorrhage / drug therapy


  • Neuroprotective Agents
  • Pregnatrienes
  • tirilazad