Comparison of DNA replication in Xenopus laevis and Simian Virus 40

Adv Exp Med Biol. 2007;604:3-16. doi: 10.1007/978-0-387-69116-9_1.


DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: origin-licensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Cycle
  • DNA / chemistry
  • DNA Replication*
  • Humans
  • Origin Recognition Complex
  • Replication Origin
  • S Phase
  • Simian virus 40 / metabolism*
  • Species Specificity
  • Xenopus laevis / metabolism*


  • Origin Recognition Complex
  • DNA