Comparative effectiveness of beta-adrenergic antagonists (atenolol, metoprolol tartrate, carvedilol) on the risk of rehospitalization in adults with heart failure

Am J Cardiol. 2007 Aug 15;100(4):690-6. doi: 10.1016/j.amjcard.2007.03.084. Epub 2007 Jun 26.


Placebo-controlled randomized trials have demonstrated the efficacy of selected beta blockers on outcomes in chronic heart failure (HF), but the relative effectiveness of different beta blockers in usual clinical care is poorly understood. We compared 12-month risk of rehospitalization for HF associated with receipt of different beta blockers in 7,883 adults hospitalized for HF within 2 large health plans between January 1, 2001 and December 31, 2002. Beta-blocker use was ascertained from electronic pharmacy databases and readmissions within 12 months were identified from hospital discharge databases. Extended Cox regression was used to examine the association between receipt of different beta blockers and risk of readmission for HF after adjustment for potential confounders. During follow-up, there were 3,234 person-years of exposure to beta blockers (39.3% atenolol, 42.0% metoprolol tartrate, 12.3% carvedilol, and 6.4% other). Crude 12-month rates of readmissions for HF were high overall (42.6 per 100 person-years). After adjustment for potential confounders, cumulative exposure to each beta blocker, and propensity to receive carvedilol compared with atenolol, adjusted risks of readmission were not significantly different for metoprolol tartrate (adjusted hazard ratio 0.95, 95% confidence interval 0.85 to 1.05) or for carvedilol (adjusted hazard ratio 0.92, 95% confidence interval 0.74 to 1.14). In conclusion, in a contemporary cohort of high-risk patients hospitalized with HF, we found that adjusted risks of rehospitalization for HF within 12 months were not significantly different in patients receiving atenolol, shorter-acting metoprolol tartrate, or carvedilol.

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Adult
  • Aged
  • Aged, 80 and over
  • Aluminum
  • Atenolol / therapeutic use*
  • California
  • Carbazoles / therapeutic use*
  • Carvedilol
  • Confidence Intervals
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Heart Failure / drug therapy*
  • Humans
  • Male
  • Metoprolol / therapeutic use*
  • Middle Aged
  • Patient Readmission / trends*
  • Propanolamines / therapeutic use*
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Tartrates / therapeutic use*
  • Time Factors
  • Treatment Outcome


  • Adrenergic beta-Antagonists
  • Carbazoles
  • Propanolamines
  • Tartrates
  • Carvedilol
  • Atenolol
  • Aluminum
  • Metoprolol
  • tartaric acid