Plasmid DNA and viral vector-based vaccines for the treatment of cancer

Vaccine. 2007 Sep 27;25 Suppl 2:B24-34. doi: 10.1016/j.vaccine.2007.05.030. Epub 2007 Jun 6.

Abstract

Plasmid DNA and viral vector-based cancer vaccines have many inherent features that make them promising cancer vaccine candidates. This review focuses on the use of plasmid DNA and viral vector vaccines to deliver tumour-specific antigens to induce a tumour-specific immune response. Examples of different antigen delivery systems that have been tested in recent clinical trials are summarised and advantages and disadvantages of a number of delivery systems and approaches are discussed. Finally, an outlook on how plasmid DNA and viral vectors might be developed further as cancer vaccines is provided.

Publication types

  • Review

MeSH terms

  • Animals
  • Cancer Vaccines / therapeutic use*
  • Drug Delivery Systems / methods*
  • Genetic Vectors / immunology
  • Humans
  • Neoplasms / therapy*
  • Plasmids / genetics
  • Vaccines, DNA / administration & dosage*
  • Vaccines, DNA / immunology
  • Viral Vaccines / therapeutic use*

Substances

  • Cancer Vaccines
  • Vaccines, DNA
  • Viral Vaccines