Role of gastrin peptides in carcinogenesis

Cancer Lett. 2007 Nov 8;257(1):1-15. doi: 10.1016/j.canlet.2007.06.017. Epub 2007 Aug 14.


Gastrin gene expression is upregulated in a number of pre-malignant conditions and established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical CCK-2R receptor, CCK-2R isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion. Here we review this network of events, highlighting the importance of cellular context for interpreting the role of gastrin peptides and a possible role for gastrin in supporting the early stage of carcinogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Cell Transformation, Neoplastic*
  • Disease Progression
  • Electron Transport Complex IV / metabolism
  • Gastrins / chemistry*
  • Gastrins / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Matrix Metalloproteinases / metabolism
  • Neoplasm Invasiveness
  • Neovascularization, Pathologic
  • Peptides / chemistry*


  • Gastrins
  • Peptides
  • Electron Transport Complex IV
  • Matrix Metalloproteinases