High-frequency ultrasound characteristics of 24 iris and iridociliary melanomas: before and after plaque brachytherapy

Arch Ophthalmol. 2007 Aug;125(8):1051-8. doi: 10.1001/archopht.125.8.1051.


Objective: To evaluate size, characteristics, and regression of iris and iridociliary melanomas on high-frequency ultrasound images before and after plaque brachytherapy.

Methods: Retrospective review of high-frequency ultrasound characteristics of 24 consecutive iris and iridociliary melanomas before and after radiation therapy.

Results: The median tumor thickness before radiation therapy was 2.3 mm (range, 1.4-4.3 mm). Nineteen iris melanomas (79%) involved the ciliary body, 18 (75%) involved the iris pigment epithelium, 11 (46%) were club shaped, and 4 (17%) caused disinsertion of the iris root. At a median follow-up of 30 months after plaque brachytherapy, the mean tumor thickness had diminished to 1.2 mm (median, 1.2 mm; range, 0.9-1.9 mm). While all tumors exhibited a reduction in thickness, no tumors showed additional regression after 30 months past treatment. Fourteen tumors (58%) were noted to have increases in internal reflectivity. There was 1 failure of local control (at 6 years), successfully treated by a second application of plaque brachytherapy.

Conclusion: High-frequency ultrasonography revealed unique tumor characteristics, quantified tumor size, and demonstrated tumor response to radiation therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brachytherapy
  • Ciliary Body / diagnostic imaging*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Iris Neoplasms / diagnostic imaging*
  • Iris Neoplasms / radiotherapy
  • Male
  • Melanoma / diagnostic imaging*
  • Melanoma / radiotherapy
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Time Factors
  • Ultrasonography
  • Uveal Neoplasms / diagnostic imaging