The penetration of cefpirome into the potential sites of pulmonary infection

J Antimicrob Chemother. 1991 Jul;28(1):79-86. doi: 10.1093/jac/28.1.79.

Abstract

The concentrations of cefpirome, a new semi-synthetic cephalosporin, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed epithelial lining fluid (ELF) concentrations to be measured in eight subjects. The mean concentration for serum was 34.5 mg/L (S.E.M. 3.3), for bronchial mucosa 19.3 mg/kg (S.E.M. 1.9) and for ELF 7.2 mg/L (S.E.M. 1.1). The progressive reduction in cefpirome concentration in serum compared to that in bronchial mucosa and ELF is consistent with the permeability characteristics of beta-lactam antimicrobials and the barriers to movement of antimicrobial agents present in the lung.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchoalveolar Lavage Fluid / metabolism
  • Cephalosporins / pharmacokinetics*
  • Cephalosporins / therapeutic use
  • Epithelium / metabolism
  • Female
  • Humans
  • Lung / metabolism*
  • Male
  • Middle Aged
  • Mucous Membrane / metabolism
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / metabolism*

Substances

  • Cephalosporins
  • cefpirome