Abstract
The expression of the adenylate kinase isozymes and of phosphopyruvate hydratase was studied in man-mouse and man-hamster hybrid clones. Concordant segregation of the loci coding for AK-2 and PPH was observed in 54 of 55 primary hybrid clones, and these loci were demonstrated to be synthetic with the loci specifying PGM-1 and PGD. The pattern of expression of the four enzymes in discordant clone suggests the gene order 1pter-(PGD, PPH)-AK-2-PGM-1-centromere. In addition, AK-1 was found to be expressed independently of AK-2.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenylate Kinase / metabolism*
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Animals
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Chromosomes / metabolism
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Clone Cells
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Female
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Humans
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Hybrid Cells / embryology*
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Isoenzymes / metabolism*
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Male
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Mice
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Phosphoglucomutase / metabolism*
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Phosphogluconate Dehydrogenase / metabolism*
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Phosphopyruvate Hydratase / metabolism*
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Phosphotransferases / metabolism*
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Translocation, Genetic
Substances
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Isoenzymes
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Phosphogluconate Dehydrogenase
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Phosphotransferases
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Adenylate Kinase
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Phosphopyruvate Hydratase
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Phosphoglucomutase