Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Physiology (Bethesda). 2007 Aug;22:252-60. doi: 10.1152/physiol.00012.2007.


Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Endothelium, Vascular / physiopathology
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology*
  • Insulin Resistance / physiology*
  • Metabolic Syndrome / physiopathology
  • Microcirculation / physiopathology*
  • Obesity / physiopathology*
  • Rats
  • Vascular Resistance / physiology