ER-mitochondria communication. How privileged?

Physiology (Bethesda). 2007 Aug;22:261-8. doi: 10.1152/physiol.00017.2007.


Mitochondria have a low affinity for Ca(2+), but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca(2+) release. This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Endoplasmic Reticulum / physiology*
  • Homeostasis / physiology
  • Humans
  • Mice
  • Mitochondria, Muscle / physiology*
  • Muscle, Skeletal / metabolism
  • Rats
  • Sarcoplasmic Reticulum / physiology


  • Calcium