Seven-year Prospective Study of Nonmelanoma Skin Cancer Incidence in U.K. Renal Transplant Recipients

Transplantation. 2007 Aug 15;84(3):437-9. doi: 10.1097/01.tp.0000269707.06060.dc.

Abstract

Nonmelanoma skin cancer (NMSC) causes significant morbidity and mortality posttransplantation. We examined the annual incidence of NMSC in U.K. renal transplant recipients (RTRs). A total of 269 (95% of potential population) RTRs of skin type I-IV were recruited into a prospective study of NMSC incidence between 1998 and 2006. A total of 244 (91% enrolled) RTRs were screened on at least one occasion. The mean incidence per year of NMSC was 7.82% (SD: 1.84), comprising a mean (SD) incidence per year of squamous cell carcinoma 3.45% (1.36), basal cell carcinoma 3.58% (1.17), and Bowen's disease 2.52% (0.91). The risk of developing NMSC increased with duration posttransplantation: the mean incidence per year of NMSC was 3.27% (0.53) in RTRs <5 years posttransplantation, 5.86% (3.1) in RTRs 5-10 years posttransplant, and 11.1% (1.85) in those >10 years posttransplant. Relatively low NMSC incidence rates within the first 5 years posttransplantation suggests that duration posttransplantation may determine the optimum frequency of surveillance of RTRs in the United Kingdom.

MeSH terms

  • Bowen's Disease / epidemiology*
  • Carcinoma, Basal Cell / epidemiology*
  • Carcinoma, Squamous Cell / epidemiology*
  • Cohort Studies
  • Humans
  • Incidence
  • Kidney Transplantation*
  • Prospective Studies
  • Risk Factors
  • Skin Neoplasms / epidemiology*
  • United Kingdom / epidemiology