Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

Br J Cancer. 2007 Oct 8;97(7):1005-8. doi: 10.1038/sj.bjc.6603932. Epub 2007 Aug 14.


Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02-1.34) for those who were overweight and 1.89 (95% CI: 1.51-2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cohort Studies
  • Humans
  • Liver Neoplasms / epidemiology
  • Liver Neoplasms / etiology*
  • Obesity / complications*
  • Overweight*
  • Risk Assessment
  • Risk Factors