Merkel cell carcinoma: more deaths but still no pathway to blame

J Invest Dermatol. 2007 Sep;127(9):2100-3. doi: 10.1038/sj.jid.5700925.


Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV--induced skin cancers and highlights the question of what drives this malignancy.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Carcinoma, Merkel Cell / epidemiology
  • Carcinoma, Merkel Cell / mortality*
  • Carcinoma, Merkel Cell / pathology*
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Incidence
  • Mitosis
  • Mutation
  • Neoplasms, Radiation-Induced / epidemiology
  • Registries
  • Signal Transduction
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / mortality*
  • Skin Neoplasms / pathology*
  • Ultraviolet Rays
  • United States