A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid

Exp Clin Endocrinol Diabetes. 2007 Jun;115(6):397-400. doi: 10.1055/s-2007-973853.


Papillary thyroid carcinoma is a slow growing tumor with low metastatic potential. The most frequent sites of distant metastases are lung and bone; less frequent sites are brain, liver, kidney, and skin. Ovarian metastases from papillary thyroid carcinoma are exceptional. We describe a case of bilateral ovarian metastases from a papillary thyroid carcinoma associated with autoimmune thyroiditis in a 38-year-old woman who underwent thyroidectomy and cervical lymph-node dissection 7 years before, followed by 948 mCi of 131I. A primary ovarian cancer could be excluded by the typical pathological aspects of a papillary thyroid carcinoma in a context of an aggressive form of thyroid cancer. On the other hand, the clinical history and the absence of normal thyroid epithelium and teratomatous components could exclude a papillary thyroid carcinoma arising in struma ovarii. This is a singular case of papillary thyroid carcinoma metastasizing to the ovary, combined with an autoimmune thyroiditis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Carcinoma, Papillary / pathology*
  • Carcinoma, Papillary / therapy
  • Female
  • Humans
  • Lymph Node Excision
  • Neoplasm Metastasis
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / secondary*
  • Ovarian Neoplasms / therapy
  • Radiotherapy Dosage
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / therapy
  • Thyroidectomy