G-proteins and GPCrs: from the beginning

Ernst Schering Found Symp Proc. 2006;(2):1-21. doi: 10.1007/2789_2006_001.


From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all.

Publication types

  • Historical Article
  • Review

MeSH terms

  • GTP-Binding Proteins / history
  • GTP-Binding Proteins / physiology*
  • History, 20th Century
  • Humans
  • Receptors, G-Protein-Coupled / history
  • Receptors, G-Protein-Coupled / physiology*


  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins