Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid

Wien Med Wochenschr. 2007;157(13-14):367-70. doi: 10.1007/s10354-007-0442-6.


Valerian and hops are traditionally used as sleep-inducing aids. Alertness reduces gradually with the prolongation of wakefulness through the release of endogenous adenosine in the frontal basal cortex. Valerian has an adenosine-like action and supports the readiness to fall asleep. The control of the sleep-wake rhythm induces sleep when the time-related interaction is operating properly. The control is closely related to endogenous melatonin secretion. Hops act in a similar way to melatonin. Therefore, the efficacy of a valerian and hops combination in sleep disorder can scientifically be explained.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Drug Combinations
  • Humans
  • Humulus* / chemistry
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Preparations
  • Rats
  • Sleep Wake Disorders / drug therapy*
  • Valerian* / chemistry


  • Drug Combinations
  • Plant Extracts
  • Plant Preparations