Schizandrin Reverses Memory Impairment in Rats

Phytother Res. 2008 Jan;22(1):49-52. doi: 10.1002/ptr.2258.

Abstract

The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Cyclooctanes / chemistry
  • Cyclooctanes / pharmacology*
  • Dose-Response Relationship, Drug
  • Lignans / chemistry
  • Lignans / pharmacology*
  • Male
  • Maze Learning / drug effects
  • Memory Disorders / chemically induced
  • Memory Disorders / prevention & control*
  • Molecular Structure
  • Muscarinic Antagonists / pharmacology
  • Oxotremorine / pharmacology
  • Phytotherapy
  • Polycyclic Compounds / chemistry
  • Polycyclic Compounds / pharmacology*
  • Rats
  • Rats, Wistar
  • Schisandra / chemistry
  • Scopolamine

Substances

  • Cyclooctanes
  • Lignans
  • Muscarinic Antagonists
  • Polycyclic Compounds
  • Oxotremorine
  • Scopolamine
  • schizandrin