Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice

Breast Cancer Res. 2007;9(4):211. doi: 10.1186/bcr1745.


This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1beta, tumour necrosis factor, interferon-gamma, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / immunology*
  • Genes, erbB-2 / immunology*
  • Inflammation
  • Mammary Glands, Animal / immunology*
  • Mammary Neoplasms, Animal* / genetics
  • Mammary Neoplasms, Animal* / immunology
  • Mammary Neoplasms, Animal* / pathology
  • Mice
  • Mice, Transgenic