Amping up estrogen receptors in breast cancer

Breast Cancer Res. 2007;9(4):305. doi: 10.1186/bcr1748.


This article highlights a recent study by Holst et al. in Nature Genetics that finds estrogen receptor-alpha (ER-alpha) amplification in early benign lesions and more advanced invasive carcinomas of the breast, and discusses the potential implications to our present understanding of the role of ER-alpha in breast tumorigenesis.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / metabolism*
  • Estrogen Receptor alpha / physiology*
  • Female
  • Humans


  • Estrogen Receptor alpha