The nephropathology in human immunodeficiency virus (HIV-1) infection

Kidney Int Suppl. 1991 Dec;35:S19-23.


The nephropathology observed in patients with HIV infection is reviewed. A characteristic, though not specific, nephropathy associated with HIV infection can be encountered in HIV carriers, in patients with AIDS-related complex and in patients with AIDS. HIV-associated nephropathy typically exhibits the features of an aggressive form of focal and segmental glomerulosclerosis. Distinctive pathologic features include: 1) the "collapsing" and predominantly global pattern of glomerulosclerosis; 2) the severity of visceral epithelial cell hypertrophy and droplet formation; 3) the prominent tubular microcysts and cast formation; 4) the focal tubular degenerative features; and 5) the numerous tubuloreticular inclusions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • AIDS-Associated Nephropathy / pathology
  • Acquired Immunodeficiency Syndrome / pathology
  • HIV Infections / pathology*
  • HIV-1*
  • Humans
  • Kidney / pathology*