Treatment of bilateral refractive amblyopia in children three to less than 10 years of age

Am J Ophthalmol. 2007 Oct;144(4):487-96. doi: 10.1016/j.ajo.2007.05.040. Epub 2007 Aug 20.

Abstract

Purpose: To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age.

Design: Prospective, multicenter, noncomparative intervention.

Methods: One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year.

Results: Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks.

Conclusions: Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amblyopia / physiopathology
  • Amblyopia / therapy*
  • Astigmatism / physiopathology
  • Astigmatism / therapy*
  • Child
  • Child, Preschool
  • Eyeglasses*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperopia / physiopathology
  • Hyperopia / therapy*
  • Male
  • Prospective Studies
  • Treatment Outcome
  • Vision, Binocular / physiology*
  • Visual Acuity / physiology*