Matrix metalloproteinases as modulators of inflammation

Semin Cell Dev Biol. 2008 Feb;19(1):34-41. doi: 10.1016/j.semcdb.2007.07.003. Epub 2007 Jul 10.


An increased expression of members of the matrix metalloproteinase (MMP) family of enzymes is seen in almost every human tissue in which inflammation is present. Through the use of models of human disease in mice with targeted deletions of individual MMPs, it has become clear that MMPs act broadly in inflammation to regulate barrier function, inflammatory cytokine and chemokine activity, and the generation of chemokine gradients. Individual MMPs regulate both normal and pathological inflammatory processes, and therefore, developing rational therapies requires further identification of specific MMP substrates and characterization of the downstream consequences of MMP proteolytic activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Capillary Permeability / physiology
  • Chemokines / antagonists & inhibitors
  • Chemokines / metabolism
  • Cytokines / metabolism
  • Humans
  • Inflammation / etiology*
  • Inflammation Mediators / metabolism
  • Matrix Metalloproteinases / metabolism
  • Matrix Metalloproteinases / physiology*
  • Substrate Specificity


  • Chemokines
  • Cytokines
  • Inflammation Mediators
  • Matrix Metalloproteinases