Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy

Antonio Giordano; Alessandra Rossi; Gaetano Romano; Luigi Bagella

doi:10.1002/jcp.21225

Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy

J Cell Physiol. 2007 Nov;213(2):403-6. doi: 10.1002/jcp.21225.

Authors

Antonio Giordano¹, Alessandra Rossi, Gaetano Romano, Luigi Bagella

Affiliation

¹ Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg., Philadelphia, Pennsylvania 19122, USA. giordsno@temple.edu

PMID: 17708530
DOI: 10.1002/jcp.21225

Abstract

Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle / physiology
Cell Proliferation
Genes, Tumor Suppressor*
Humans
Multigene Family
Neoplasms* / genetics
Neoplasms* / metabolism
Neoplasms* / therapy
Protein Structure, Tertiary
Retinoblastoma-Like Protein p130 / chemistry*
Retinoblastoma-Like Protein p130 / genetics
Retinoblastoma-Like Protein p130 / metabolism*

Substances

RBL2 protein, human
Retinoblastoma-Like Protein p130