Three cases of endometrial cancer associated with "bioidentical" hormone replacement therapy

Med J Aust. 2007 Aug 20;187(4):244-5. doi: 10.5694/j.1326-5377.2007.tb01210.x.


We describe three women who developed endometrial cancer after taking "bioidentical" hormone replacement therapy (HRT) to relieve menopausal symptoms. Although pharmaceutical HRT is a well established and tested therapy, little is known about the quality control, safety and efficacy of bioidentical HRT. Women should be advised to avoid bioidentical HRT, and those who continue to use it should receive regular endometrial surveillance.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biological Products / adverse effects*
  • Biological Products / chemistry*
  • Drug Compounding*
  • Endometrial Neoplasms / chemically induced*
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / surgery
  • Estrogen Replacement Therapy / adverse effects*
  • Female
  • Humans
  • Middle Aged


  • Biological Products