Protein phosphorylation and the nuclear organization of pre-mRNA splicing

Trends Cell Biol. 1997 Apr;7(4):135-8. doi: 10.1016/S0962-8924(96)20043-1.


Controlled execution of transcription and pre-mRNA splicing is crucial for proper gene expression. The organization of these essential events within the cell nucleus is only beginning to be understood. Here, we describe a model for the cellular arrangement of transcription and pre-mRNA splicing based on recent biochemical and morphological data: transcription and pre-mRNA splicing are spatially and temporally coordinated, and protein phosphorylation regulates both the activity and the subnuclear localization of pre-mRNA splicing factors in nuclear subcompartments.