Slow axonal transport: the subunit transport model

Trends Cell Biol. 1997 Oct;7(10):384-8. doi: 10.1016/S0962-8924(97)01133-1.


A central problem concerning slow transport of cytoskeletal proteins along nerve axons is where they are assembled and the form in which they are transported. The polymer and subunit transport models are the two major hypotheses. Recent developments using molecular and cellular biophysics, molecular cell biology and gene technology have enabled visualization of moving forms of cytoskeletal proteins during their transport. Here, we argue that these studies support the subunit transport theory.