AMPK links energy status to cell structure and mitosis

Biochem Biophys Res Commun. 2007 Nov 3;362(4):789-92. doi: 10.1016/j.bbrc.2007.08.016. Epub 2007 Aug 10.

Abstract

AMP-activated protein kinase (AMPK) is known as an important cellular energy sensor, but its in vivo role has not been fully understood. Recent studies provided surprising results that AMPK regulates cell polarity and mitosis under the control of tumour suppressor LKB1. Moreover, these newly found in vivo functions of AMPK are regulated by energy status in a cell autonomous manner. These findings provide novel insights into the physiological function of AMPK and the treatment of AMPK-related diseases such as cancer and diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Polarity / physiology*
  • Cell Size
  • Energy Metabolism / physiology*
  • Humans
  • MAP Kinase Signaling System / physiology*
  • Mitosis / physiology*
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*

Substances

  • Protein Kinases
  • AMP-activated protein kinase kinase
  • STK11 protein, human
  • Protein-Serine-Threonine Kinases