High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival

Am J Clin Pathol. 2007 Sep;128(3):430-6. doi: 10.1309/C6X54HRB580EP2NQ.

Abstract

There is sufficient evidence that human stomatin-like protein 2 (SLP-2) is a novel cancer-related gene. Its protein is overexpressed in many human cancers. SLP-2 can contribute to the promotion of cell growth, cell adhesion, and tumorigenesis in esophageal squamous cell carcinoma and lymph node metastasis in laryngeal squamous cell carcinoma. Immunohistochemical detection of SLP-2, estrogen and progesterone receptors, and HER-2/neu were performed on 263 cases of primary invasive breast cancer with a tissue microarray. Of 263 cases, 138 (52.5%) showed high expression of SLP-2 protein, and 125 (47.5%) showed low or absent expression. In addition, there were significant positive associations between tumor stage and size (P = .020), lymph node metastasis (P < .001), clinical stage (P < .001), distant metastasis (P = .002), and HER-2/neu protein expression (P = .037) and high-level SLP-2 expression. High-level SLP-2 expression was associated with decreased overall survival (P = .011) and was more often found in patients with tumors larger than 20 mm, lymph node metastasis, advanced clinical stage, distant metastasis, and HER-2/neu protein-positive expression. More important, lymph node metastasis, HER-2/neu-positive expression, and high-level SLP-2 expression were associated with significantly decreased survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor
  • Blood Proteins / metabolism*
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / mortality
  • Female
  • Humans
  • Immunohistochemistry
  • Membrane Proteins / metabolism*
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • Receptor, ErbB-2 / metabolism*
  • Survival Analysis

Substances

  • Biomarkers, Tumor
  • Blood Proteins
  • Membrane Proteins
  • STOML2 protein, human
  • Receptor, ErbB-2