Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

J Leukoc Biol. 2007 Dec;82(6):1375-81. doi: 10.1189/jlb.0607338. Epub 2007 Aug 20.


The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Chemokines / metabolism*
  • Humans
  • Inflammation*
  • Leukocytes / cytology*
  • Leukocytes / enzymology*
  • Matrix Metalloproteinases / metabolism*
  • Protein Processing, Post-Translational*


  • Chemokines
  • Matrix Metalloproteinases