Case report: "Purely" psychiatric presentation of multiple sclerosis in an adolescent boy

J Am Acad Child Adolesc Psychiatry. 2007 Sep;46(9):1213-1217. doi: 10.1097/chi.0b013e3180ca86bf.


We present the case of a 14-year-old Hispanic boy with a 6-month history of a psychotic disorder necessitating several hospitalizations who was incidentally found to have multiple sclerosis with no physical findings. Neuropsychological assessment has revealed impairments in word-finding, bilateral fine motor skills, and attention. Imaging and laboratory studies have supported the diagnosis of multiple sclerosis. Steroid and immunomodulating therapy has not significantly affected psychiatric symptoms. He has had poor response to psychotropic medications as well. We discuss the implications of multiple sclerosis as the cause of this patient's psychiatric illness.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / diagnosis*
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Attention Deficit Disorder with Hyperactivity / psychology*
  • Central Nervous System Stimulants / therapeutic use
  • Diagnosis, Differential
  • Humans
  • Male
  • Methylphenidate / therapeutic use
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / psychology*
  • Neurologic Examination


  • Central Nervous System Stimulants
  • Methylphenidate