Mechanisms of Tumor Growth and Metastasis in Head and Neck Squamous Cell Carcinoma

Curr Treat Options Oncol. 2007 Jun;8(3):227-38. doi: 10.1007/s11864-007-0032-2.


The formation and progression of head and neck squamous cell carcinoma (HNSCC) is multisystemic and involves the immune system, vascularization, and dissemination. Immune involvement includes the subversion of anti-tumor defenses. Vascularization involves both angiogenesis and vasculogenesis. Dissemination involves local tumor invasion as well as distant metastasis through processes including angiogenesis and lymphangiogenesis. Current studies in the dysregulation of various processes, including genetic stability, angiogenesis, lymphangiogenesis, immune regulation, and immune function, are opening opportunities for the development of targeted tumor therapies. The interrelationship of these processes in HNSCC development will be explored in this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / blood supply
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / secondary
  • Disease Progression
  • Head and Neck Neoplasms / blood supply
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Neoplasm Metastasis
  • Neovascularization, Pathologic / pathology