Integrating molecular and network biology to decode endocytosis

Nature. 2007 Aug 23;448(7156):883-8. doi: 10.1038/nature06031.


The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation.

MeSH terms

  • Cell Physiological Phenomena
  • Clathrin / metabolism*
  • Endocytosis*
  • Molecular Biology*
  • Protein Binding
  • Synaptic Vesicles / metabolism
  • Terminology as Topic


  • Clathrin