Can we do better than a single estimated GFR threshold when screening for chronic kidney disease?

Kidney Int. 2007 Sep;72(5):534-6. doi: 10.1038/


The Modification of Diet in Renal Disease (MDRD) equation has been used to screen for and diagnose chronic kidney disease (CKD). A fixed estimated glomerular filtration rate cutoff point has been advocated by the National Kidney Foundation to diagnose CKD. However, data derived from healthy individuals challenge this approach and suggest that age- and gender-specific reference values may be more useful in the screening setting.

Publication types

  • Comment

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Failure, Chronic / diagnosis*
  • Male
  • Mass Screening / methods
  • Middle Aged
  • Reference Values
  • Renal Insufficiency, Chronic / diagnosis*
  • Sex Factors