One-pot synthesis of 2,3-dihydro-1H-benzimidazoles

Sergey V Ryabukhin; Andrey S Plaskon; Dmitry M Volochnyuk; Alexander N Shivanyuk; Andrey A Tolmachev

doi:10.1021/jo0712087

One-pot synthesis of 2,3-dihydro-1H-benzimidazoles

J Org Chem. 2007 Sep 14;72(19):7417-9. doi: 10.1021/jo0712087. Epub 2007 Aug 23.

Authors

Sergey V Ryabukhin¹, Andrey S Plaskon, Dmitry M Volochnyuk, Alexander N Shivanyuk, Andrey A Tolmachev

Affiliation

¹ Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine.

PMID: 17715977
DOI: 10.1021/jo0712087

Abstract

A convenient one-pot method for the synthesis of 2,3-dihydro-1H-benzimidazoles has been elaborated. A set of 2,3-dihydro-1H-benzimidazoles was prepared from various ortho-dialkylaminoanilines and aldehydes using Me3SiCl as a condensation agent and pyridine as a basic medium.