Targeted delivery of multifunctional magnetic nanoparticles

Nanomedicine (Lond). 2007 Apr;2(2):153-67. doi: 10.2217/17435889.2.2.153.


Magnetic nanoparticles and their magnetofluorescent analogues have become important tools for in vivo imaging using magnetic resonance imaging and fluorescent optical methods. A number of monodisperse magnetic nanoparticle preparations have been developed over the last decade for angiogenesis imaging, cancer staging, tracking of immune cells (monocyte/macrophage, T cells) and for molecular and cellular targeting. Phage display and data mining have enabled the procurement of novel tissue- or receptor-specific peptides, while high-throughput screening of diversity-oriented synthesis libraries has identified small molecules that permit or prevent uptake by specific cell types. Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Contrast Media / chemistry*
  • Drug Delivery Systems / methods*
  • Image Enhancement / methods*
  • Magnetics / therapeutic use*
  • Nanomedicine / trends*
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use*


  • Contrast Media