Borealin is repressed in response to p53/Rb signaling

Cell Biol Int. 2007 Dec;31(12):1470-81. doi: 10.1016/j.cellbi.2007.06.013. Epub 2007 Jul 15.


Rb/E2F regulates many genes that encode proteins required for the cell cycle. Using affymetrix microarrays we previously identified genes regulated by the Rb proteins p130 and p107, many of which are involved in the cell cycle. Several genes with unknown functions were also repressed by p130 and p107, of which some have recently been found to have various roles in mitosis, the spindle checkpoint and cytokinesis. This study focuses on the regulation of borealin/dasra/cdca8, which encodes a recently discovered member of the chromosomal passenger complex. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing / genetics
  • Biomarkers, Tumor / metabolism
  • Cell Cycle
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Division / genetics
  • E2F Transcription Factors / genetics
  • E2F Transcription Factors / metabolism
  • Gene Expression Regulation / physiology*
  • Gene Silencing
  • Genes, p53 / physiology*
  • HCT116 Cells
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Retinoblastoma-Like Protein p107 / genetics
  • Retinoblastoma-Like Protein p107 / metabolism
  • Retinoblastoma-Like Protein p130 / genetics
  • Retinoblastoma-Like Protein p130 / metabolism
  • Signal Transduction / physiology*
  • Transcription, Genetic
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*


  • Biomarkers, Tumor
  • CDCA8 protein, human
  • Cell Cycle Proteins
  • E2F Transcription Factors
  • Retinoblastoma Protein
  • Retinoblastoma-Like Protein p107
  • Retinoblastoma-Like Protein p130
  • Tumor Suppressor Protein p53