Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 8 (9), 741-52

Self-eating and Self-Killing: Crosstalk Between Autophagy and Apoptosis

Affiliations
Review

Self-eating and Self-Killing: Crosstalk Between Autophagy and Apoptosis

M Chiara Maiuri et al. Nat Rev Mol Cell Biol.

Abstract

The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.

Similar articles

See all similar articles

Cited by 1,074 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback