Cost, causes and rates of rehospitalization of preterm infants

J Perinatol. 2007 Oct;27(10):614-9. doi: 10.1038/ Epub 2007 Aug 23.


Objective: To examine hospital readmissions for premature infants during the first year of life.

Study design: The California maternal and newborn/infant hospital discharge records were examined for subsequent readmission during the first year of life for all newborns from 1992 to 2000. Discharge diagnoses, hospital days, demographic data and hospital charges for infants born preterm (<36 weeks gestation) were identified and evaluated.

Result: About 15% of preterm infants required at least one rehospitalization within the first year of life (average cost per readmission 8,468 dollars, average annual cost in excess of 41 million dollars). Infants with gestational age <25 weeks had the highest rate of readmission (31%) and longest average length of stay (12 hospital days). The largest cohort, infants born at 35 weeks gestation, had the highest total cost of readmission (92.9 million dollars). The most common cause of rehospitalization was acute respiratory disease. There was no decrease in the number or cost of readmissions of premature infants for respiratory syncytial virus infections following the introduction of palivizumab in 1998.

Conclusion: After initial discharge, premature infants continue to have significant in-patient health-care needs and costs.

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents / therapeutic use
  • Birth Weight
  • California / epidemiology
  • Gestational Age
  • Hospital Charges
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Premature, Diseases / economics
  • Infant, Premature, Diseases / therapy*
  • Length of Stay
  • Needs Assessment*
  • Palivizumab
  • Patient Readmission / economics
  • Patient Readmission / statistics & numerical data*
  • Respiratory Syncytial Virus Infections / drug therapy
  • Respiratory Syncytial Virus Infections / epidemiology
  • Retrospective Studies
  • Utilization Review*


  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents
  • Palivizumab