microRNAs: A Safeguard Against Turmoil?

Cell. 2007 Aug 24;130(4):581-5. doi: 10.1016/j.cell.2007.08.010.

Abstract

Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Humans
  • MicroRNAs / genetics*
  • Models, Biological
  • Stress, Physiological*
  • Transcription, Genetic

Substances

  • MicroRNAs